Raf Kinase Inhibitor Protein (RKIP) Dimer Formation Controls Its Target Switch from Raf1 to G Protein-coupled Receptor
نویسندگان
چکیده
Background: Raf kinase inhibitor protein (RKIP) is a regulator of several distinct kinases, including Raf1 and G proteincoupled receptor kinase 2 (GRK2). Results: Protein kinase C-mediated phosphorylation of RKIP triggers dimer formation of RKIP, which enables RKIP to switch specificity between Raf1 and GRK2. Conclusion: Phosphorylation-dependent dimerization of RKIP coordinates specific interactions with Raf1 and GRK2. Significance: Control switches in a kinase regulator permit specific control of multiple kinase signaling pathways and their downstream functions.
منابع مشابه
Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2.
Proteins controlling cellular networks have evolved distinct mechanisms to ensure specificity in protein-protein interactions. Raf kinase inhibitor protein (RKIP) is a multifaceted kinase modulator, but it is not well understood how this small protein (21 kDa) can coordinate its diverse signaling functions. Raf1 and G protein-coupled receptor kinase (GRK) 2 are direct interaction partners of RK...
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